The ability to accurately characterize foveal morphology represents an important first step in separating out retinal versus cortical contributions to visual deficits in these patients. The HHP SD-OCT scanner was encased via the Animal Imaging Mount (AIM) (Bioptigen, Inc., Durham, NC), which allowed forward and backward adjustment of the HHP (Figure 3b). The spectrum of foveal morphology seen in albinism is greater than previously thought. We observed considerable variation in foveal morphology in individuals with albinism - 9 had planar retinal thickness, 6 had mounding at the incipient foveal location but no pit, 7 had mounding and a subtle foveal depression, and 1 had nearly normal foveal morphology (foveal depth = 0.028 mm, foveal diameter = 1.58 mm, foveal volume = 0.016 mm 3). Normal foveal pit depth ranged from 0.032 to 0.177 mm, diameter ranged from 1.17 to 2.65 mm, and volume ranged from 0.024 to 0.21 mm 3. Dimensions of all OCT scans were corrected for individual differences in axial length in order to ensure accurate absolute measures of pit dimensions. The preclinical OCT solutions provide insight into eye disease research, while the clinical OCT systems serve as an aid in diagnosing pathological conditions.
#BIOPTIGEN SD OCT SOFTWARE#
Custom Matlab software was used to derive estimates of the depth, diameter, slope, and volume of the foveal pit from the retinal thickness data sets. Seven subjects were imaged using the hand-held probe of the Bioptigen system, as they were imaged off-site at the National Conference of the National Organization for Albinism and Hypopigmentation (NOAH). Cross-sectional and/or volumetric SD-OCT images of the macula were obtained using the Cirrus HD-OCT or the Bioptigen SD-OCT. We recruited 139 individuals with normal vision (71 male, 68 female mean age = 27 yrs) and 23 individuals with albinism (6 OA1, 17 OCA mean age = 24 yrs). We sought to quantify foveal morphology in individuals with albinism and compare this to normal foveal morphology using newly developed foveal pit metrics. Albinism is typically characterized by foveal hypoplasia, although recent data have demonstrated variation in the degree of hypoplasia.
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